Towards Efficient Incident Detection in Real-time Traffic Management

Incident detection is a key component in real-time traffic management systems that allows efficient response plan generation and decision making by means of risk alerts at critical affected sections in the network. State-of-the-art incident detection techniques traditionally require: i) good quality data from closely located sensor pairs, ii) a minimum of two reliable measurements from the flow- occupancy-speed triad, and iii) supervised adjustment of thresholds that will trigger anomalous traffic states. Despite such requirements may be reasonably achieved in simulated scenarios, real-time downstream applications rarely work under such ideal conditions and must deal with low reliability data, missing measurements, and scarcity of curated incident labelled datasets, among other challenges. This paper proposes an unsupervised technique based on univariate timeseries anomaly detection for computationally efficient incident detection in real-world scenarios. Such technique is proved to successfully work when only flow measurements are available, and to dynamically adjust thresholds that adapt to changes in the supply. Moreover, results show good performance with low-reliability and missing data

Redes sociales y gestión de ventas en Valquiria Corporación S.A.C., Callao, 2021

El presente trabajo de investigación denominado Redes sociales y gestión de ventas en Valquiria Corporación S.A.C., Callao, 2021. Se desarrolló con el objetivo principal de determinar la relación de las redes sociales y gestión de ventas en Valquiria Corporación S.A.C., Callao, 2021. La metodología utilizada fue de tipo aplicada con un nivel correlacional, enfoque cuantitativo, diseño no experimental de corte transversal. Asimismo, la población y muestra estuvo conformada por 42 colaboradores de la empresa Valquiria Corporación S.A.C, La técnica de recolección de datos fue la encuesta por medio del cuestionario compuesto de 20 preguntas provenientes de la descomposición de las variables de estudio y debidamente validadas por medio de juicio de expertos y fiabilidad de Alfa de Cronbach. Del mismo modo, para un mayor entendimiento y enriquecer la investigación se recurrió a teorías como la teoría de las redes sociales, el uso de la teoría de redes sociales en la representación y análisis de textos, la teoría de redes sociales y las políticas públicas creada por Gonzalez, teoría de demanda, Teoría AIDA y Teoría de la Cantidad Descontada. Los resultados obtenidos lograron demostrar una correlación positiva considerable entre las redes sociales y gestión de ventas en Valquiria Corporación S.A.C., demostrada por una correlación de Pearson positiva moderada (0,666), representativa para la población (p-valor de 0,000)

Las Actitudes de los docentes y la percepción frente a la inclusión de los estudiantes con discapacidad intelectual en las II.EE. inclusivas primarias de Barranco y Chorrillos

El objetivo de esta investigación es “Determinar la relación entre Las Actitudes de los docentes y la inclusión educativa de los estudiantes con Discapacidad Intelectual en las II.EE. inclusivas primarias de Barranco y Chorrillos en el año 2012” dicho estudio se fundamenta en el análisis del cumplimiento de una escuela para todos que exige reorientar los procesos técnicos pedagógicos de gestión y fundamentalmente, la innovación constante de sus agentes educativos; de tal forma que las II.EE. de los diferentes niveles y modalidades apuntan al esfuerzo en los retos que todavía plantea esta educación; desde luego fortaleciendo la cultura y la práctica inclusiva en la escuela, el desarrollo profesional de la docencia, articulando el trabajo educativo en los cambios y fomentando la responsabilidad social para la educación. La investigación se realizó bajo la metodología Hipotético Deductivo en el enfoque cuantitativo positivista que se orienta a la recolección y análisis de datos siguiendo el diseño no experimental, descriptivo explicativo y correlacional ya que por medio del análisis y descripción de las variables, los datos estadísticos que sostiene esta investigación vienen de los resultados obtenidos de la aplicación de los instrumentos a los docentes, validados por los expertos de las Instituciones Inclusivas entre ellas tenemos cuestionarios aplicados a los antes mencionados. Las conclusiones indican que existe una correlación directa y significativa entre las actitudes de los docentes frente al proceso de inclusión educativa de los estudiantes con Necesidades Educativas Especiales asociadas a un nivel de discapacidad leve

Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis

<p>Abstract</p> <p>Background</p> <p>Cysteine proteases have been shown to be highly relevant for Apicomplexan parasites. In the case of <it>Babesia bovis</it>, a tick-transmitted hemoparasite of cattle, inhibitors of these enzymes were shown to hamper intraerythrocytic replication of the parasite, underscoring their importance for survival.</p> <p>Results</p> <p>Four papain-like cysteine proteases were found to be encoded by the <it>B. bovis </it>genome using the MEROPS database. One of them, the ortholog of <it>Plasmodium falciparum </it>falcipain-2, here named bovipain-2, was further characterized. Bovipain-2 is encoded in <it>B. bovis </it>chromosome 4 by an ORF of 1.3 kb, has a predicted molecular weight of 42 kDa, and is hydrophilic with the exception of a transmembrane region. It has orthologs in several other apicomplexans, and its predicted amino acid sequence shows a high degree of conservation among several <it>B. bovis </it>isolates from North and South America. Synteny studies demonstrated that the <it>bovipain-2 </it>gene has expanded in the genomes of two related piroplasmids, <it>Theileria parva </it>and <it>T. annulata</it>, into families of 6 and 7 clustered genes respectively. The <it>bovipain-2 g</it>ene is transcribed in <it>in vitro </it>cultured intra-erythrocyte forms of a virulent and an attenuated <it>B. bovis </it>strain from Argentina, and has no introns, as shown by RT-PCR followed by sequencing. Antibodies against a recombinant form of bovipain-2 recognized two parasite protein bands of 34 and 26 kDa, which coincide with the predicted sizes of the pro-peptidase and mature peptidase, respectively. Immunofluorescence studies showed an intracellular localization of bovipain-2 in the middle-rear region of <it>in vitro </it>cultured merozoites, as well as diffused in the cytoplasm of infected erythrocytes. Anti-bovipain-2 antibodies also reacted with <it>B. bigemina</it>-infected erythrocytes giving a similar pattern, which suggests cross-reactivity among these species. Antibodies in sera of two out of six <it>B. bovis</it>-experimentally infected bovines tested, reacted specifically with recombinant bovipain-2 in immunoblots, thus demonstrating expression and immunogenicity during bovine-infecting stages.</p> <p>Conclusions</p> <p>Overall, we present the characterization of bovipain-2 and demonstrate its <it>in vitro </it>and <it>in vivo </it>expression in virulent and attenuated strains. Given the involvement of apicomplexan cysteine proteases in essential parasite functions, bovipain-2 constitutes a new vaccine candidate and potential drug target for bovine babesiosis.</p

Sustainable development goals and ending ECC as a public health crisis

Early Childhood Caries (ECC) remains a global issue despite numerous advancements in research and interventional approaches. Nearly, 530 million children suffer from untreated dental caries of primary teeth. The consequences of such untreated dental caries not only limit the child's chewing and eating abilities but also, significantly impact the child's overall growth. Research has demonstrated that ECC is associated with nearly 123 risk factors. ECC has also been associated with local pain, infections, abscesses, and sleep pattern. Furthermore, it can affect the child's emotional status and decrease their ability to learn or perform their usual activities. In high-income countries, dental care continues to endorse a “current treatment-based approach” that involves high-technology, interventionist, and specialized approaches. While such approaches provide immediate benefit at an individual level, it fails to intercept the underlying causes of the disease at large. In low-income and middle-income countries (LMICs), the “current treatment approach” often remains limited, unaffordable, and unsuitable for the majority of the population. Rather, dentistry needs to focus on “sustainable goals” and integrate dental care with the mainstream healthcare system and primary care services. Dental care systems should promote “early first dental visits,” when the child is 1 year of age or when the first tooth arrives. The serious shortages of appropriately trained oral healthcare personnel in certain regions of the world, lack of appropriate technologies and isolation of oral health services from the health system, and limited adoption of prevention and oral health promotion can pose as critical barriers. The oral health care systems must focus on three major keystones to combat the burden of ECC−1. Essential oral health services are integrated into healthcare in every country ensuring the availability of appropriate healthcare accessible and available globally, 2. Integrating oral and general healthcare to effectively prevent and manage oral disease and improve oral health, 3. Collaborating with a wide range of health workers to deliver sustainable oral health care tailored to cater to the oral health care needs of local communities

Three new bricks in the wall: Berkeley 23, Berkeley 31, and King 8

A comprehensive census of Galactic open cluster properties places unique constraints on the Galactic disc structure and evolution. In this framework we investigate the evolutionary status of three poorly-studied open clusters, Berkeley 31, Berkeley 23 and King 8, all located in the Galactic anti-centre direction. To this aim, we make use of deep LBT observations, reaching more than 6 mag below the main sequence Turn- Off. To determine the cluster parameters, namely age, metallicity, distance, reddening and binary fraction, we compare the observational colour-magnitude diagrams (CMDs) with a library of synthetic CMDs generated with different evolutionary sets (Padova, FRANEC and FST) and metallicities. We find that Berkeley 31 is relatively old, with an age between 2.3 and 2.9 Gyr, and rather high above the Galactic plane, at about 700 pc. Berkeley 23 and King 8 are younger, with best fitting ages in the range 1.1-1.3 Gyr and 0.8-1.3 Gyr, respectively. The position above the Galactic plane is about 500- 600 pc for the former, and 200 pc for the latter. Although a spectroscopic confirmation is needed, our analysis suggests a sub-solar metallicity for all three clusters.Comment: 17 Pages, Accepted for publication in MNRA

Validation and field evaluation of a competitive enzyme-linked immunosorbent assay for diagnosis of Babesia bovis infections in Argentina

Infections by Babesia bovis limit cattle production and cause important economic losses in tropical and subtropical areas around the world. Monitoring of calf sera can be used to detect unprotected cattle herds and to decide on strategic control measures, as well as for epidemiological studies. Merozoite surface antigen 2c (MSA-2c) is an immunodominant surface protein expressed in B. bovis merozoites and sporozoites and contains B-cell epitopes that are conserved among geographic isolates. A monoclonal antibody against recombinant MSA-2c (rMSA-2c) was previously shown to inhibit the binding of anti-B. bovis antibodies to a parasite B-cell epitope in a competitive enzyme-linked immunosorbent assay (cELISA) format. In the work at hand, the parameters of this cELISA were reevaluated and adjusted when necessary, and a cutoff value was determined by receiver operator characteristic (ROC) curve analysis of a total of 357 bovine sera of known reactivity, as assessed by indirect immunofluorescence assay (IFAT). The established rMSA-2c cELISA demonstrated a specificity of 98% and a sensitivity of 96.2%. An additional set of 303 field bovine sera from regions where ticks are endemic and tick-free regions of Argentina was tested by both rMSA-2c cELISA and IFAT, and the results were shown to be in very good agreement (kappa index, 0.8325). The performance shown by rMSA-2c cELISA in the detection of B. bovis-specific antibodies and its suitability for standardization and large-scale production, as well as the possibility of its application in most veterinary diagnostic laboratories, make the assay a powerful tool for the surveillance of herd immunity as a strategic measure for the control of bovine babesiosis.Fil: Dominguez, Mariana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; ArgentinaFil: Echaide, Ignacio Eduardo. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Torioni de Echaide, Susana Marta. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Wilkowsky, Silvina Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Zabal, Osvaldo Alfredo. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; ArgentinaFil: Mosqueda, Juan J.. Universidad Autonoma de Queretaro.; MéxicoFil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; ArgentinaFil: Jacobsen, Monica Ofelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentin

Old open clusters and the Galactic metallicity gradient: Berkeley 20, Berkeley 66, and Tombaugh 2

To study the crucial range of Galactocentric distances between 12 and 16 kpc, where little information is available, we have obtained VI CCD imaging of Berkeley 20 and BVI CCD imaging of Berkeley 66 and Tombaugh 2, three distant, old open clusters. Using the synthetic colour magnitude diagram (CMD) technique with three types of evolutionary tracks of different metallicities, we have determined age, distance, reddening and indicative metallicity of these systems. The CMD of Be 20 is best reproduced by stellar models with a metallicity about half of solar (Z=0.008 or 0.01), in perfect agreement with high resolution spectroscopic estimates. Its age is between 5 and 6 Gyr from stellar models with overshooting and between 4.3 and 4.5 Gyr from models without it. The distance modulus from the best fitting models is always (m-M)0=14.7 (corresponding to a Galactocentric radius of about 16 kpc), and the reddening E(B-V) ranges between 0.13 and 0.16. A slightly lower metallicity (Z ~ 0.006) appears to be more appropriate for Be 66. This cluster is younger, (age of 3 Gyr), and closer, (m-M)0=13.3 (i.e., at 12 kpc from the Galactic centre), than Be 20, and suffers from high extinction, 1.2 < E(B-V) < 1.3, variable at the 2-3 per cent level. Finally, the results for To 2 indicate that it is an intermediate age cluster, with an age of about 1.4 Gyr or 1.6-1.8 Gyr for models without and with overshooting, respectively. The metallicity is about half of solar (Z=0.006 to 0.01), in agreement with spectroscopic determinations. The distance modulus is (m-M)0=14.5, implying a distance of about 14 kpc from the Galactic centre; the reddening E(B-V) is 0.31-0.4, depending on the model and metallicity, with a preferred value around 0.34.Comment: 19 pages, 19 figures, 8 tables Accepted 2010 November 5. Received 2010 Novembe